The early childhood workforce encompasses a range of professionals across health care, early childhood education, mental health, child welfare, and early intervention. Despite the differences in daily responsibilities, these professionals experience similar systems-level challenges which impede their ability to professionally flourish and risk undermining the needs of families. In this article, we highlight four key challenges—compensation, burnout, safety, and retention—which have long impacted their sectors and have been further exacerbated by the pandemic. Opportunities for policymakers and program administrators to discuss these challenges are discussed. (author abstract)